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It has been well known that prostaglandins E and F are effective in uterine contraction on both pregnant and nonpregnant uterus, Since 1969 when Karim reported that prostaglandin F₂αwas effective in induction of labor, many researches have been published with different results because of different route of adminiftration, different dosage or standard of observation. A clinical study was carried out to know clinical reaction of prostaglandin F2a for induction of labor. Induction of labor was performed in 53 women who were on 36 to 44 weeks of normal gestation. The prostaglandin F2a was administered by continuous intravenous drip infusion started from dosage of 4.0ug per minute. The results were as follows: 1. Induction failed on 10.53% of primiparas, in 2.94% of multiparas, and overall failure ra te was 5.66% on the average. 2. Failure rate on cases with in cases with intact membrane was 14.28% in pimiparas, 3, 33% in multiparas, and 0% in the group of premature rupture of membrane. 3. Failure rate in the group with pelvic score 0-5 was 33.33% in primiparas, 8.33% in multiparas, and overall failure rate was 16.67% while 0% in the easy group with pelvic score 6 or more. 4. Lag period was 21 minutes in primiparas and 25 minutes in multiparas on the average. 5. Total doses of prostaglandin F₂ used for induction of labor were 2,850mg in primipar as and 1,752mg in multiparas. 6. Mean labor hours were 5.55 hours in primiparas and 3.53 hours in multiparas. 7. Postpartum atonic bleeding was 6% after induction of labor with prostaglandin F₂ 8. Side effects of prostaglandin F2a were mild in few cases : Facial flusing, nausea and vomiting were disappeared without specific treatment. 9. Newborn babys` conditions were excellent with Apgar score over 8 in one minute of their age.
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